Structural formula
| Business number | 014S |
|---|---|
| Molecular formula | C8H11NO3 |
| Molecular weight | 169.18 |
| label |
Norepinephrine, (R)-4-(2-amino-1-hydroxyethyl)-1,2-benzenediol, (R)-4-(2-Amino-1-hydroxyethyl)-1,2-benzenediol, L-Arterenol, L-Noradrenaline, Levarterenol |
Numbering system
CAS number:51-41-2
MDL number:MFCD00025592
EINECS number:200-096-6
RTECS number:DN5950000
BRN number:2804840
PubChem number:24891196
Physical property data
1. Properties: Off-white to brown fine crystals. Sensitive to light and air.
2. Density (g/mL, 25/4℃): Undetermined
3. Relative vapor density (g/mL, air=1): Undetermined
4. Melting point (ºC): 216.5～218℃ (decomposition)
5. Boiling point (ºC, normal pressure): Undetermined
6. Boiling point (ºC, 5.2kPa): Not determined
7. Refractive index: Not determined
8. Flash point (ºC): Not determined
9. Specific rotation ( º): [α]D25 -37.3° (C=5, in 1mol/L hydrochloric acid)
10. Autoignition point or ignition Temperature (ºC): Undetermined
11. Vapor pressure (kPa, 25ºC): Undetermined
12. Saturated vapor pressure (kPa, 60ºC): Undetermined
13. Heat of combustion (KJ/mol): Undetermined
14. Critical temperature (ºC): Undetermined
15. Critical pressure (KPa): Undetermined
16. The logarithmic value of the oil-water (octanol/water) partition coefficient: Undetermined
17. The upper limit of explosion (%, V/V): Undetermined
18. Lower explosion limit (%, V/V): Undetermined
19. Solubility: Soluble in inorganic acids and alkali, slightly soluble in water, methanol, ethanol and ether.
Toxicological data
None
Ecological data
None
Molecular structure data
1. Molar refractive index: 44.63
2. Molar volume (cm3/mol): 121.0
3. Isotonic specific volume (90.2K ): 358.3
4. Surface tension (dyne/cm): 76.7
5. Polarizability (10-24cm3): 17.69
Compute chemical data
1. Reference value for hydrophobic parameter calculation (XlogP): None
2. Number of hydrogen bond donors: 4
3. Number of hydrogen bond acceptors:4
4. Number of rotatable chemical bonds: 2
5. Number of tautomers: 10
6. Topological molecule polar surface area 86.7
p>
7. Number of heavy atoms: 12
8. Surface charge: 0
9. Complexity: 142
10. Number of isotope atoms :0
11. Determine the number of atomic stereocenters: 1
12. Uncertain number of atomic stereocenters: 0
13. Determine the chemical bond configuration Number of centers: 0
14. Number of uncertain chemical bond stereocenters: 0
15. Number of covalent bond units: 1
Properties and stability
None
Storage method
Seal with argon and store at 4℃ to avoid light.
Synthesis method
It can be made from catechol and chloroacetyl chloride to 3,4-dihydroxy-2-chloroacetophenone, and then reacted with ammonia or methenamine.
Purpose
Anti-shock vasoactive drugs. It is mainly used to rescue acute hypotension and shock caused by peripheral vasodilation.
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